USGS Western Ecological Research Center

Home Who We Are Where We Are What We Do Products Search Outreach Jobs Contacts

Toward immunogenetic studies of amphibian chytridiomycosis: linking innate and acquired immunity

Released: 2009
Richmond, JQ, AE Savage, KR Zamudio, EB Rosenblum. 2009. Toward immunogenetic studies of amphibian chytridiomycosis: linking innate and acquired immunity. Bioscience 59(4): 311-320. doi: 10.1525/bio.2009.59.4.9

Recent declines in amphibian diversity and abundance have contributed significantly to the global loss of biodiversity. The fungal disease chytridiomycosis is widely considered to be a primary cause of these declines, yet the critical question of why amphibian species differ in susceptibility remains unanswered. Considerable evidence links environmental conditions and interspecific variability of the innate immune system to differential infection responses, but other sources of individual, population, or species-typical variation may also be important. In this article we review the preliminary evidence supporting a role for acquired immune defenses against chytridiomycosis, and advocate for targeted investigation of genes controlling acquired responses, as well as those that functionally bridge the innate and acquired immune systems. Immunogenetic data promise to answer key questions about chytridiomycosis susceptibility and host-pathogen coevolution, and will draw much needed attention to the importance of considering evolutionary processes in amphibian conservation management and practice.

Information about this product can be downloaded from this location:

Bookmark and Share


Accessibility FOIA Privacy Policies and Notices

Take Pride in America logo logo U.S. Department of the Interior | U.S. Geological Survey
Page Contact Information:

References to non-U.S. Department of Interior (DOI) products do not constitute an endorsement by the DOI.

* DOI and USGS link policies apply.